Independent drug appraisals, free of industry influence
The The Medical Letter subscription exists to answer one question honestly: is this new drug actually better? Its critical reviews appraise new medicines and compare therapeutic options head to head, and because it accepts no pharmaceutical-industry funding, its recommendations rest on evidence rather than marketing — a rare thing in drug information.
Inside this resource
Critical, not promotional
Each review takes a new drug and asks what the evidence really shows about its benefit, harm and place in therapy — a critical appraisal rather than the optimistic framing that surrounds a product launch.
Comparisons in The Medical Letter subscription
Head-to-head comparisons of treatment options are the heart of its usefulness: not just whether a drug works, but whether it works better than what you already prescribe, which is the decision that actually faces a clinician.
Independent by design
It takes no funding from the pharmaceutical industry, and that independence is the whole point — the recommendations are shaped by evidence alone, giving you a source you can weigh against the promotional material that fills your inbox.
Who this serves
- Prescribing clinicians — an honest read on whether a new drug is worth switching to.
- Formulary and P&T committees — independent comparisons to inform coverage decisions.
- Pharmacists — evidence-first appraisals free of industry framing.
Before you buy
Is it independent of drug companies?
Yes — it accepts no pharmaceutical-industry funding, so its recommendations are based purely on evidence.
Does it compare treatments?
Yes — head-to-head comparisons of therapeutic options are central to what it offers.
The chart
| Format | Clinical reference (subscription) |
|---|---|
| Approach | Independent, industry-free reviews |
| Content | New-drug appraisals and comparisons |
| Publisher | The Medical Letter |
| Department | Research |
| Delivery | Emailed once your order is verified |



D. Rossi –
Refreshingly critical. It will tell you a shiny new drug adds little, which is worth a lot.
pt_committee –
We lean on the head-to-head comparisons for formulary decisions. Independent and evidence-first — exactly what a P&T committee needs.
Dr. Grace H. –
The one drug source I trust precisely because it takes no industry money. Its verdict on a new agent talked me out of an expensive switch that the reps were pushing hard.
Dr. Aiko M. –
Concise and honest appraisals. I read it before believing any launch hype now.
pharm_neil –
Invaluable for unbiased reviews. It is text-focused rather than flashy, and coverage follows what is newly relevant, but the independence is unmatched.